Idea #1:
Spring load the chamber against the barrel with a gasket in between.

Con- The spring mechanism needs to be engaged/disengaged everytime a chamber is moved into place.
Idea #2:
RevoSemi. The gasketed insert moves forward under pressure to seal the transition.

Con- Not alot, but there may be a simpler idea.
Idea #3:
Similar to the last idea, a rubber gasket flexs under pressure to seal the clearance between barrel/chamber.
[picture in attachments]
Con- Rubber exposed directly to combustion. May not be a long term option.
Any other ideas?