Well, structurally speaking, there are no obvious, glaring problems. Assuming a decent quality steel with 60KSI tensile yield strength, you'll have a safety factor of at least 2 on the chamber, 1.5 on the barrel, and 5 on the rear cap (if I've remembered how to calculate failure pressure of a flat plate correctly).
Unfortunately, it's not as simple as this - holes in pressure vessels can cause much less predictable structural behaviour. This varies with the size and geometry of the hole, and can be worse if the hole is threaded. Your safety factor of six may drop to less than two. It may do to increase plate thickness to 50mm or so on the rear cap. As for the chamber-barrel coupling; I don't know how you plan on attaching your barrel, but it will also be a concern. If you're going to weld it...
Well, it had better be a hell of a good weld
There will need to be some HGDT work done here to determine just how long the thicker barrel sections need to be, but that shouldn't be much of an issue.
The bolts, assuming they are of at least moderate quality and evenly tensioned, will be in no danger of simple tensile failure, and will have a safety factor of 3 - 6 in that regard, dependent upon their grade. Because of the potential for uneven loading, you'll want the highest grade you can get, probably grade 8 (there are bolts available that far exceed grade 8 specs, but they're uncommon and expensive, generally).
More of a concern may be thread stripping on the bolts. If you use high grade nuts as well, the safety factor will be lower than that for tensile failure of the bolts, roughly three.
So there you have it. Ragnarok will be able to tell you more about the front plate issue, and how to solve it. You'll find that fueling and ignition design are more of a problem for high mix hybrids than is the structure itself. Also, I assure you that aligning everything and sealing the burst disk will be
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